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Long-Term Effects of Nicotine Use Variations between the immediate and delayed response of the digestive system towards cigarette smoking over short-term or long-term periods are: Short-term effects of nicotine During this period users may observe a sudden alteration in their bowel habits including an increase in frequency accompanied by loose consistency, commonly known as diarrhea

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Further experimental details are provided in the Methods section, with additional information on the cigarettes and sampling techniques presented in Supplementary Sections S1 and S2, respectively

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